I think it isn’t a concern if you are going to centrifuge the honey out. However, @Dee started a long and somewhat amusing discussion on another thread when she posted this comment:
My thought is that if the feces is trapped between the outside of the cocoon and the plastic cell wall of the Flow frame, any honey running down through the cell wall split has the possibility of washing some larval poo into the honey. Minute amounts, sure, but enough of a chance that I wouldn’t sell it. I might feed it back to the bees, or give it away to problematic neighbours…
